Recombinant Human IL-2 Protein (GMP Grade)
Catalog Number： PM101-01
Price：Please inquire first
Product Details
Interleukin-2 (IL-2), also referred to as T cell growth factor, was the first interleukin molecule to be cloned. It binds to the IL-2 receptor (IL-2R) and stimulates T cell proliferation, thereby enabling long-term survival of T cells in vitro [1]. Additionally, IL-2 enhances the proliferative and cytotoxic activity of natural killer (NK) cells by binding to IL-2R on their surface [2]. IL-2 is a pleiotropic cytokine that promotes the proliferation of tumor-infiltrating lymphocytes, stimulates B cell proliferation for immunoglobulin production, and activates macrophages to enhance their phagocytic function [3]. The recombinant human IL-2 protein consists of 134 amino acids and is produced in Chinese Hamster Ovary (CHO) cells. It is subsequently isolated, highly purified, and subjected to lyophilization.
Storage
at room temperature for two years.
Shipping
Room temperature
1 Malek TR: The Biology of Interleukin-2. Annual Review of Immunology 2008, 26(1):453-479.
2 Becker PSA, Suck G, Nowakowska P, Ullrich E, Seifried E, Bader P, Tonn T, Seidl C: Selection and expansion of natural killer cells for NK cell-based immunotherapy. Cancer Immunology, Immunotherapy 2016, 65(4):477-484.
3 Gaffen S, Liu K: Overview of interleukin-2 function, production and clinical applications. Cytokine 2004, 28(3):109-123.
